Asundexian
规格
| Cas Number | 2064121-65-7(DMSO) |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 级别 | Moligand™ |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Factor Xa,Metabolic Enzyme/Protease,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Asundexian（BAY 2433334）是一种口服活性凝血因子 Xia（FXIa）抑制剂。Asundexian 能直接、有效、可逆地与 FXIa 的活性位点结合，从而抑制其活性。Asundexian 可抑制缓冲液中的人 FXIa，其 IC 50 |
| 英文描述 |
Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC 50 of 1 nM. In Vivo Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |