Abemaciclib metabolite M2
规格
| Cas Number | 1231930-57-6 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 2 mg/mL (4.18 mM; Need ultrasonic) |
| 过滤标签 | CDK,Drug Metabolite,Cell Cycle/DNA Damage,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Abemaciclib 代谢物 M2（LSN2839567）是 Abemaciclib 的代谢物，是一种强效的 CDK4 和 CDK6 抑制剂，其 IC 50 s 分别为 1.2 和 1.3 nM。抗癌活性。 |
| 英文描述 |
Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC 50 s of 1.2 and 1.3 nM, respectively. Anti-cancer activity In Vivo Abemaciclib metabolite M2 (LSN2839567) is bound to plasma proteins in rat, dog and human (83-92%), lower than Abemaciclib (95-99%). Abemaciclib metabolite M2 is the most prominent (active and major) plasma metabolites in human. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CDK4 1.2 nM (IC 50 ) CDK6 1.3 nM (IC 50 ) |