AZD5423
规格
| Cas Number | 1034148-04-3 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| Action Type | 调节剂 |
| Mechanism Of Action | 糖皮质激素受体调节剂 |
| 溶解性 | DMSO : 100 mg/mL (205.15 mM; Need ultrasonic) |
| 过滤标签 | Glucocorticoid Receptor,Immunology/Inflammation,Vitamin D Related/Nuclear Receptor |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | AZD5423 是一种吸入式、强效、选择性和非甾体类糖皮质激素受体（GR）调节剂（SGRM）。AZD5423 能有效降低轻度过敏性哮喘患者的过敏原诱导反应。 |
| 英文描述 |
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM) AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma . In Vitro The affinity of AZD5423 to the glucocorticoid receptor is high with an IC 50 of 0.9 nM in a radioligand human glucocorticoid receptor assay, and selectivity towards other steroid hormone receptors is >900-fold. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Glucocorticoid receptor |