Bruceantinol
规格
| Cas Number | 53729-52-5 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 英文简短描述 | Terpenoids Triterpenes |
| 过滤标签 | STAT,JAK/STAT Signaling,Stem Cell/Wnt,Terpenoids Triterpenes |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Bruceantinol 是一种从 Brucea javanica 中分离出来的醌类化合物，对辣椒中的辣椒斑驳病毒有抑制作用。Bruceantinol 是一种 STAT3 抑制剂，在体外和体内人类结直肠癌（CRC）模型中显示出强大的抗肿瘤活性。布鲁斯坦醇 |
| 英文描述 |
Bruceantinol, a quassinoid isolated from Brucea javanica , inhibits pepper mottle virus in pepper Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability ( IC 50 =2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1 , PTTG1, survivin and c-Myc . Form:Solid IC50& Target:IC 50 : 2.4 pM (STAT3 DNA-binding ability) |