Chroman 1
规格
| Cas Number | 1273579-40-0(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | ROCK,TGF-beta/Smad,Cell Cycle/DNA Damage,Stem Cell/Wnt,Cytoskeleton,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Chroman 1 是一种高效、选择性的 ROCK 抑制剂。Chroman 1 对 ROCK2 的抑制作用（IC 50 =1 pM）强于 ROCK1（IC 50 =52 pM）。Chroman 1 对 MRCK 也有抑制活性，IC 50 为 150 nM。 |
| 英文描述 |
Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM In Vitro Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation. IC50& Target:ROCK2|1 pM (IC|50|)|ROCK1|52 pM (IC|50|)|MRCK|150 nM (IC|50|) |