Carboxylesterase-IN-2
规格
| Cas Number | 2764748-88-9 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 50 mg/mL (183.60 mM; Need ultrasonic) |
| 过滤标签 | Wnt,Stem Cell/Wnt |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 羧基酯酶-IN-2（化合物 4u）是羧基酯酶 Notum 的强效抑制剂，其 IC 50 小于或等于 10 nM。Notum 是一种通过水解棕榈油酸酯而起作用的 Wnt 信号转导负调控因子，而棕榈油酸酯是 Wnt 信号转导所必需的。 |
| 英文描述 |
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC 50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease. Form:Solid |