CTB
规格
| Cas Number | 451491-47-7 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (290.93 mM; Need ultrasonic) |
| 过滤标签 | 表观遗传学,Histone Acetyltransferase |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | CTB 是一种强效的 p300 组蛋白乙酰转移酶激活剂。CTB 能有效诱导 MCF-7 细胞凋亡。 |
| 英文描述 |
CTB is a potent p300 histone acetyltransferase activator CTB can effectively induce apoptosis in MCF-7 cells . In Vitro CTB (10, 50, 100, 150, 200, and 250 μM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. ?\nCTB (0-200 μM; 24 hours) inhibits the viability of MCF-7 cells with an IC 50 of 85.43 μM. ?\nCTB (85.43 μM; 24, 48 and 72 h) induces time dependence apoptosis of MCF-7 cells. ?\nCTB (50 uM; 24?h) increases p300/CBP activity , and reduces autophagic flux in primary neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cell Concentration: 0-200 μM Incubation Time: 24 hours Result: Inhibit viability with an IC 50 of 85.43 μM. Apoptosis AnalysisCell Line: MCF-7 cell Concentration: 85.43 μM Incubation Time: 24, 48 and 72 h Result: Iinduced time-dependence apoptosis. Form:Solid IC50& Target:CBP/p300 |