Echistatin，α1亚型，TFA盐
规格
| Cas Number | 154303-05-6(free base) |
| 规格或纯度 | ≥95% |
| 纯度 | ≥95% |
| 包装 | 100μg 或 500μg |
产品信息
| 品牌 | 阿拉丁 |
| 氨基酸 | Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr |
| 溶解性 | Soluble to 1 (mg/mL) in water |
| 序列 | ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT(Modifications: Disulfide bridge between 2 - 11, 7 - 32, 8 - 37, 20 - 39) |
| 简短描述 | αVβ3和糖蛋白IIb / IIIa（整联蛋白αIIbβ3）抑制剂 |
| 英文简短描述 | αVβ3and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor |
| 过滤标签 | Integrin,Cytoskeleton |
| 储存温度 | 避光,-20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 强效不可逆的αVβ3整联蛋白拮抗剂（Ki = 0.27 nM）。破坏破骨细胞与骨骼的附着并抑制骨骼的重吸收（IC50 = 0.1 nM）。通过在体外抑制糖蛋白IIb / IIIa（GpIIb / IIIa，αIIbβ3）受体（IC50 = 30 nM）来防止ADP诱导的血小板聚集。 |
| 英文描述 |
Potent irreversible αVβ3 Integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced Platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro. Application： Echistatin has been used:as an inhibitor of integrin function to study the role of microfibril-associated glycoprotein-1 (Magp1) in the morphogenesis of vascular structures for the preparation of microbubbles targeted to αvβ3 integrins in tumor angiogenesis imaging as a conjugate to αvβ3 in flow cytometric binding studies |