FIDAS-5
规格
| Cas Number | 1391934-98-7 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 250mg 或 50mg 或 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 125 mg/mL (477.61 mM; Need ultrasonic) |
| 过滤标签 | 表观遗传学,Methionine Adenosyltransferase (MAT),Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | FIDAS-5 是一种强效的蛋氨酸 S-腺苷转移酶 2A（MAT2A）口服活性抑制剂，IC50 为 2.1 μM。FIDAS-5 能有效竞争 S-腺苷蛋氨酸（SAM）与 MAT2A 的结合。FIDAS-5 具有抗癌活性。 |
| 英文描述 |
FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC 50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities In Vitro FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. ?\nFIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-5 induces the expression of cell cycle inhibitor, p21 WAF1/CIP1. ?\nFIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: LS174T colorectal cancer (CRC) cells Concentration: 3 μM Incubation Time: 7 days Result: Significantly inhibited the proliferation of LS174T cells. In Vivo FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight . ?\nMice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 16 athymic nude mice injected with HT29 CRC cells Dosage: 20 mg/kg Administration: Oral gavage; daily; for two weeks Result: Significantly inhibited the growth of xenograft tumors. Form:Solid IC50& Target:IC50: 2.1 μM (Methionine S-adenosyltransferase 2A (MAT2A)) |