GDC-0575 (ARRY-575)
规格
| Cas Number | 1196541-47-5(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 溶解性 | Solubility (25°C) In vitro DMSO: 7 mg/mL (28.84 mM); Ethanol: 5 mg/mL (20.6 mM); Water: Insoluble; |
| 简短描述 | Chk1 选择性抑制剂 |
| 英文简短描述 | Chk1 Selective Inhibitors |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | GDC-0575（ARRY-575，RG7741）是一种强效的选择性 CHK1 抑制剂，IC50 为 1.2\u2009nM。 |
| 英文描述 |
Information GDC-0575 (ARRY-575, RG7741) is a potent and selectiveCHK1inhibitor with an IC50 of 1.2 nM. GDC-0575 enhances the cytotoxicity of Cytarabine (AraC) in vitro. In vivo GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor that results in tumor shrinkage and growth delay in xenograft models. cell lines：various cancer cell lines belonging to 4 types of cancer—breast, ovarian, prostate, and endometrial cancer—in which the PIK3CA mutation and PTEN deficiency are frequently found and in which RAS/RAF is rarely mutated Concentrations： Incubation Time： Powder Purity:≥98% |