GNF-PF-3777
规格
| Cas Number | 77603-42-0 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 6.4 mg/mL (21.83 mM; Need warming) |
| 过滤标签 | Indoleamine 2，3-Dioxygenase (IDO),Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | GNF-PF-3777（8-硝基色黄素）是一种强效的人类吲哚胺 2,3-二氧合酶 2（h IDO2）抑制剂，可显著降低 IDO2 的活性，其 K i 为 0.97 μM。 |
| 英文描述 |
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (h IDO2 ) inhibitor which significantly reduces IDO2 activity with K i of 0.97 μM. In Vitro The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC 50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC 50 of 0.82 μM. GNF-PF-3777 (8-Nitrotryptanthrin) has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:rhIDO2 1.8 μM (IC 50 ) rhIDO2 0.97 μM (Ki) |