IMD-0560

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¥ 2,450.90 2450.9 CNY ¥ 2,450.90

¥ 2,200.90

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规格或纯度 10mM in Ethanol
货号(SKU) I654919
品牌 阿拉丁
  • 包装

此组合不存在。

条款和条件
30天退款保证
运输:2-3 个工作日

规格


Cas Number 439144-66-8(Ethanol)
规格或纯度 10mM in Ethanol
包装 1ml

产品信息


品牌 阿拉丁
浓度 10mM in Ethanol
过滤标签 NF-κB,IKK
储存温度 -80℃储存
运输条件 超低温冰袋运输
生化和生理学机理 IMD-0560 是一种新型 IκB 激酶 β 抑制剂。
英文描述

IMD-0560 is a novel IκB kinase β inhibitor.

In Vitro

Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IKKβ

技术规格说明书


质检证书(CoA,COO,BSE/TSE)