5J-4
规格
| Cas Number | 827001-82-1 |
| 规格或纯度 | ≥95% |
| 纯度 | ≥95% |
| 包装 | 10mg |
产品信息
| 品牌 | 阿拉丁 |
| 过滤标签 | CRAC Channel,膜转运器/离子通道 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 5J-4 是一种强效的 CRAC 抑制剂。5J-4 可减少中枢神经系统内浸润的单核细胞数量，并显著减少浸润的 CD4+ 细胞数量。5J-4 可减轻 EAE（实验性自体脑炎）的症状并延缓其发病。 |
| 英文描述 |
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation. In Vivo 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt . 5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice (MOG35-55 peptide-immunized mice) Dosage: 2 m/kg Administration: I.p., every alternate day for 30 days Result: Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population. Form:Powder |