JC-1
规格
| Cas Number | 47729-63-5 |
| 规格或纯度 | A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria. |
| 包装 | 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria. |
| 溶解性 | DMSO: 5 mg/mL |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 物理形态 | 固体 |
| 生化和生理学机理 | 主要靶标<br>用作细胞，组织和分离的线粒体中线粒体电位δΨm的比率指示剂产物不与ATP竞争。可逆：否细胞渗透性：否 |
| 描述 |
一种阳离子、荧光、碳菁染料，可用作细胞、组织和分离的线粒体中线粒体电位ΔΨm的比率指示剂。线粒体去极化由红色/绿色荧光强度比的降低指示。电位敏感的色移是由于红色荧光J聚集体的浓度依赖性形成。非常适合检测由线粒体呼吸解偶联剂诱导的ΔΨm衰竭。JC-1还已用于多药耐药细胞的功能测定和凋亡相关的线粒体修饰。一种阳离子、荧光、碳菁染料，可用作细胞、组织和分离的线粒体中线粒体电位ΔΨm的比率计指示剂。它用高膜电位橙色标记线粒体，用低膜电位绿色标记线粒体。线粒体去极化由红色/绿色荧光强度比的降低指示。非常适合检测由线粒体呼吸解偶联剂诱导的ΔΨm衰竭。电位敏感的色移是由于红色荧光J聚集体的浓度依赖性形成。JC-1还已用于多药耐药细胞的功能测定和凋亡相关的线粒体修饰。 |
| 英文描述 |
A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨm in cells, tissues, and isolated mitochondria. It labels mitochondria with high membrane potential orange and mitochondria with low membrane potential green. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. Ideal for detection of collapse of ΔΨm induced by uncouplers of mitochondrial respiration. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications. A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨm in cells, tissues, and isolated mitochondria. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. Ideal for detection of collapse of ΔΨm induced by uncouplers of mitochondrial respiration. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.
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