LIT-001
规格
| Cas Number | 2245072-21-1 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (154.87 mM; Need ultrasonic) |
| 过滤标签 | Oxytocin Receptor,GPCR/G Protein |
| 储存温度 | 2-8°C储存,干燥 |
| 运输条件 | 冰袋运输 |
| 生化和生理学机理 | LIT-001 是首个非肽催产素受体（OT-R）激动剂（EC 50 =55 nM；K i =226 nM）。LIT-001 可改善自闭症小鼠模型的社会互动。 |
| 英文描述 |
LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist ( EC 50 =55 nM; K i =226 nM). LIT-001 improves social interaction in a mouse model of autism In Vitro In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Oprm1 –/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background) Dosage: 10, 20 mg/kg Administration: i.p. Result: Alleviated core symptoms in the context of ASD. Form:Solid IC50& Target:EC50: 55 nM (OT-R), Ki: 226 nM (OT-R) |