MS140
规格
| Cas Number | 2229974-83-6 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 别名 | XY028-140 |
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | CDK抑制剂 |
| 英文简短描述 | CDK Inhibitors |
| 过滤标签 | 脂质PEG,糖聚乙二醇,PROTAC linker,Compound libraries,Hybrid Linkers,E3 Ligand |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | MS140 是一种特异性强的 CDK4/6 激酶抑制剂，也是一种 CDK4/6 降解剂（PROTAC）。 |
| 英文描述 |
Information MS140 MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC). Targets CDK4 ; CDK6 In vitro MS140 potently and selectively both inhibits and degrades CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4–CRBN–E3 ubiquitin complex. In vivo Treatment of mice with MS140 promoted degradation of CDK4/6 kinases and suppression of RB–E2F output in JeKo-1 (MCL) and Colo25 (colorectal carcinoma) xenografts in vivo. Cell Research(from reference) Cell lines：Colo205 cells Concentrations：0.3\u2009μM Incubation Time：5\u2009h |