Mardepodect hydrochloride
规格
| Cas Number | 2070014-78-5(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Phosphodiesterase (PDE),Metabolic Enzyme/Protease,Compound libraries |
| 储存温度 | 干燥,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Mardepodect hydrochloride（PF-2545920 盐酸盐）是一种强效、具有口服活性和选择性的 PDE10A 抑制剂，其 IC 50 为 0.37 nM，与其他 PDE 相比，选择性大于 1000 倍。Mardepodect 盐酸盐可透过血脑屏障。 |
| 英文描述 |
Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs . Mardepodect hydrochloride can cross the blood-brain barrier In Vivo In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED 50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.37 nM (PDE10A) |