Merafloxacin
规格
| Cas Number | 91188-00-0 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 11.11 mg/mL (29.28 mM; ultrasonic and adjust pH to 3 with HCl) |
| 过滤标签 | SARS-CoV冠状病毒,Anti-infection |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 美拉沙星（CI-934）是一种氟喹诺酮类抗菌剂，是一种选择性的β冠状病毒-1核糖体框架转换（-1 PRF）抑制剂。美拉沙星对革兰氏阳性菌和革兰氏阴性菌具有体外活性。 |
| 英文描述 |
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses . Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria In Vitro Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC 50 s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 19.6 μM (SARS-CoV-2) |