Methotrexate α-tert-butyl ester
规格
| Cas Number | 79640-70-3 |
| 规格或纯度 | ≥96% |
| 纯度 | ≥96% |
| 包装 | 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 过滤标签 | Antifolate,Cell Cycle/DNA Damage |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 由 OtBu 封端的甲氨蝶呤 α-叔丁酯可显著减少 HT1080 肿瘤小鼠的肿瘤生长。甲氨蝶呤是一种抗代谢药和抗叶酸药，也是一种免疫抑制剂和抗肿瘤药。 |
| 英文描述 |
Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent. In Vitro OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice . The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells) Dosage: 30 mg/kg Administration: Once per week for 2 weeks Result: Showed a significant (63%) reduction in tumor size on day 12. Form:Solid |