PF-06747711
规格
| Cas Number | 1892576-58-7 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 41.67 mg/mL (83.76 mM; Need ultrasonic) |
| 过滤标签 | ROR,Metabolic Enzyme/Protease,Vitamin D Related/Nuclear Receptor |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | PF-06747711 是一种强效、选择性和口服活性视黄酸受体相关孤儿 C2（RORC2，又称 RORγt）逆激动剂，其 IC 50 为 4.1 nM。抗皮肤炎症活性。 |
| 英文描述 |
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 ( RORC2 , also known as RORγt ) inverse agonist, with an IC 50 of 4.1 nM. Anti-skin inflammatory activity In Vitro PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC 50 of 9.5 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8−10 week old female Balb/c mice Dosage: 10, 30, and 100 mg/kg Administration: P.O. daily over 5 days Result: Inhibited ear swelling, and caused a maximum inhibition of 46% at 100 mg/kg. Form:Solid IC50& Target:IC50: 4.1 nM (RORC2) |