2'，3'-cGAMP钠盐
规格
| Cas Number | 2734858-36-5 |
| 规格或纯度 | Moligand™, ≥98% |
| 级别 | Moligand™ |
| 纯度 | ≥98% |
| 包装 | 10mg 或 1mg 或 5mg |
产品信息
| 别名 | 2′,5′-3′,5′-cGAMP; cGAMP(2′-5′);c[G(2′,5′)pA(3′,5′)p] 钠盐;环化[G(2′,5′)pA(3′,5′)p];2',3'-环鸟苷酸单磷酸腺苷 |
| 品牌 | 阿拉丁 |
| Action Type | 激动剂 |
| Mechanism Of Action | 干扰素反应刺激因子 cGAMP 交互因子 1 的激动剂 |
| 溶解性 | Solubility (25°C) In vitro Water: 50 mg/mL (69.6 mM); DMSO: 12.5 mg/mL (17.4 mM); |
| 简短描述 | STING 活化剂 |
| 英文简短描述 | STING Activators |
| 过滤标签 | stimulator of interferon response cGAMP interactor 1 Agonist,STING,IFNAR,Immunology/Inflammation |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | 2',3'-cGAMP（2'-3'-环 GMP-AMP Sodium Salt）是哺乳动物细胞在对细胞质中的 DNA 作出反应时产生的，能与 STING 高亲和力结合，是干扰素-β（IFNβ）的有效诱导剂。2',3'-cGAMP 与 STING 的结合 Kd 为 3.79 nM。 |
| 英文描述 |
Information 2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ) . 2',3'-cGAMP binds to STING with Kd of 3.79 nM. Targets STING (Cell-free assay) 3.79 nM(Kd) In vitro 2\',3\'-cGAMP is an endogenous second messenger produced by mammalian cells. 2\',3\'-cGAMP is a high affinity ligand for STING. 2\',3\'-cGAMP is a potent inducer of type-I interferons. 2\',3\'-cGAMP binding induces conformational changes of STING. Cell Research(from reference) Cell lines：A549, BSC-40, BSR-T7, Vero cells Concentrations：25 μM, 20 μM, 2.5 μM Incubation Time：30 min |