硫肉豆蔻酰
规格
| Cas Number | 1429749-41-6 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 50mg 或 5mg 或 25mg 或 2mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 100 mg/mL (171.86 mM); Ethanol: 100 mg/mL warmed with 50ºC Water: bath (171.86 mM); Water: Insoluble; |
| 简短描述 | Sirtuin 抑制剂 |
| 英文简短描述 | Sirtuin Inhibitors |
| 过滤标签 | 表观遗传学,Sirtuin,Cell Cycle/DNA Damage |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Thiomyristoyl (TM) 是一种强效的特异性 SIRT2 抑制剂，其 IC50 值为 28 nM。它抑制 SIRT1 的 IC50 值为 98 μM，即使在 200 μM 时也不会抑制 SIRT3。 |
| 英文描述 |
Information Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. Targets SIRT2 (Cell-free assay) 28 nM In vitro Thiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM. In vivo The anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice. Cell Research(from reference) Cell lines：breast cancer cell lines MCF-7 Concentrations：1, 5, 10, 25, 50 μM Incubation Time：6 h |