β-Amyloid (1-40) (rat)
规格
| Cas Number | 144409-98-3 |
| 规格或纯度 | ≥95% |
| 纯度 | ≥95% |
| 包装 | 1mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table: Contents Assign value Acidic amino acid Asp (D), Glu (E), a |
| 过滤标签 | Amyloid-β,神经元信号传导 |
| 储存温度 | 避光,干燥,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | β-淀粉样蛋白（1-40）（大鼠）是一种大鼠形式的淀粉样β肽，它以不溶性细胞外沉积物的形式在神经元周围积聚，形成与阿尔茨海默病（AD）相关的老年斑。 |
| 英文描述 |
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45 Ca 2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease. In Vitro β-Amyloid (1-40) (rat) (1 μM; 1 h) increases 45 Ca 2+ influx and elevates Ca 2+ in cortical synaptosomes. β-Amyloid (1-40) (rat) (3 nM) induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield and induces apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo β-Amyloid (1-40) (rat) (1.7 mg; ICV, for 7 d; swiss and C57BL/6 mice) induces the learning and memory deficits in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Swiss and C57BL/6 miceDosage: 1.7 mg Administration: Intracerebroventrical injection; for 7 days Result: Presented spatial learning and memory impairments. Form:Solid |