Ac-FLTD-CMK
规格
| Cas Number | 2376255-48-8 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 100 mg/mL (175.73 mM); Ethanol: 25 mg/mL (43.93 mM); Water: 2 mg/mL (3.51 mM); |
| 简短描述 | 半胱天冬酶抑制剂 |
| 英文简短描述 | Caspase Inhibitors |
| 过滤标签 | Apoptosis,Caspase,Pyroptosis,Immunology/Inflammation |
| 储存温度 | 避光,-20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 英文描述 |
Information Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively. Targets caspases-1 (Cell-free assay); caspases-5 (Cell-free assay); caspases-4 (Cell-free assay) 46.7 nM; 329 nM; 1.49 μM In vitro A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes. In vivo Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury. Cell Research(from reference) Cell lines：BMDM cells Concentrations：10 μM Incubation Time：30 mins |