AGI-24512
规格
| Cas Number | 2201066-53-5 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 1mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 125 mg/mL (312.13 mM; Need ultrasonic) |
| 过滤标签 | 表观遗传学,Methionine Adenosyltransferase (MAT),Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | AGI-24512 是一种强效的蛋氨酸腺苷转移酶 2α （MAT2A）抑制剂，IC50 为 8 nM。AGI-24512 触发 DNA 损伤反应。AGI-24512 可在体外阻断缺失 MTAP 的癌细胞的增殖。AGI-24512 可用于研究抗肿瘤药物。 |
| 英文描述 |
AGI-24512 is a potent methionine adenosyltransferase 2α ( MAT2A ) inhibitor, with an IC 50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro . AGI-24512 can be used for researching anticancer In Vitro AGI-24512 (0-1 μM; 96 hours) blocks proliferation of MTAP (methylthioadenosine phosphorylase)-deleted HCT116 cancer cells with an IC 50 of 100 nM. AGI-24512 significantly increases in γH2AX-positive cells in MTAP -/- HCT116 cells. AGI-24512 inhibits PRMT5-mediated SDMA marks with an IC 50 of 95 nM in MTAP -/- cells. AGI-24512 leads to a dose-dependent decrease in SAM (S-adenosylmethionine) levels in the HCT116 MTAP- cell, with an IC 50 of 100 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AGI-24512 shows poor oral absorption and a short half-life in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 8 nM (MAT2A) |