AZD-8529 mesylate
规格
| Cas Number | 1314217-69-0 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 41.67 mg/mL (71.40 mM; Need ultrasonic) |
| 过滤标签 | mGluR,GPCR/G Protein,神经元信号传导 |
| 储存温度 | 2-8°C储存,干燥 |
| 运输条件 | 冰袋运输 |
| 生化和生理学机理 | AZD-8529 甲磺酸盐是一种强效、高选择性和口服生物可用性的 mGluR2 阳性异构调节剂，EC 50 为 285 nM，在 20-25 M 时对 mGluR1、3、4、5、6、7 和 8 亚型无阳性异构调节剂反应。 |
| 英文描述 |
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 , with an EC 50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1 , 3, 4, 5, 6, 7, and 8 subtypes In Vitro AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC 50 of 195 nM. AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys . AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley rats Dosage: 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection; 2 hours before nicotine injections Result: Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats. Form:Solid IC50& Target:mGluR2 285 nM (EC 50 ) |