BVDV-IN-1
规格
| Cas Number | 345651-04-9(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | DNA/RNA Synthesis,Cell Cycle/DNA Damage,Compound libraries |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | BVDV-IN-1 是一种牛病毒性腹泻病毒（BVDV）非核苷抑制剂（NNI），EC 50 为 1.8 μM。BVDV-IN-1 可直接与 BVDV RdRp 的疏水口袋结合。BVDV-IN-1 对 NNI 硫代氨基甲酸乙酯耐药的 BVDV 具有抗病毒活性。 |
| 英文描述 |
BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV) , with an EC 50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC). In Vitro BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp). BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |