BPN-15606
规格
| Cas Number | 1914989-49-3(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | γ-secretase,Stem Cell/Wnt,神经元信号传导,Compound libraries |
| 储存温度 | 充氩,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | BPN-15606 是一种高效的口服活性γ-分泌酶调节剂（GSM），可减少 SHSY5Y 神经母细胞瘤细胞产生的 Aβ42 和 Aβ40，IC 50 值分别为 7 nM 和 17nM。BPN-15606 可降低中枢神经系统中的 Aβ42 和 Aβ40 水平 |
| 英文描述 |
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC 50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance In Vivo BPN-15606 (oral administration; 10 mg/kg, 25 mg/kg and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice . BPN-15606 (oral administration; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of Aβ42 and Aβ40 levels in rats . BPN-15606 (oral administration; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following the single dose administration and lasted for ≥24 hours in C57BL/6 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:γ-secretase |