BC1618
规格
| Cas Number | 2222094-18-8 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 83 mg/mL (199.78 mM); Ethanol: 83 mg/mL (199.78 mM); Water: Insoluble; |
| 简短描述 | AMPK 活化剂 |
| 英文简短描述 | AMPK Activators |
| 过滤标签 | 表观遗传学,E1/E2/E3 Enzyme,AMPK,Metabolic Enzyme/Protease,PI3K/Akt/mTOR |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | BC1618 是一种口服活性 Fbxo48 抑制剂，可刺激单磷酸腺苷（AMP）激活的蛋白激酶（Ampk）依赖性信号传导。BC1618 可促进线粒体裂变、促进自噬并改善肝脏对胰岛素的敏感性。 |
| 英文描述 |
Information BC1618 BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate (AMP)-activated protein kinase (Ampk)-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity. Targets Fbxo48 In vitro BC1618 interrupts Fbxo48/pAmpkα interaction. BC1618 facilitates mitochondrial fission and autophagy. In vivo Consistent with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice. Cell Research(from reference) Cell lines：293T cells Concentrations：3 μM Incubation Time：30\u2009min |