BRD0209
规格
| Cas Number | 1597439-87-6 |
| 规格或纯度 |
| 包装 | 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 62.5 mg/mL (179.88 mM; Need ultrasonic) |
| 过滤标签 | GSK-3,Stem Cell/Wnt,PI3K/Akt/mTOR |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | BRD0209 是一种强效、选择性的 GSK3α/β 双抑制剂（GSK3α IC 50 = 19 nM；GSK3β IC 50 = 5 nM）。BRD0209 还是一种可逆的 ATP 竞争性抑制剂，具有快速关闭动力学（K i = 4.2 nM）。BRD0209 是一种三环吡唑类抑制剂。 |
| 英文描述 |
BRD0209 is a potent, selective and dual inhibitor of GSK3α/β inhibitor (GSK3α IC 50 = 19 nM; GSK3β IC 50 = 5 nM). BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics ( K i = 4.2 nM, respectively). BRD0209 is a tricyclic pyrazolotetrahydroquinolinone compound. BRD0209 has the potential for the research of mood disorder diseases. Form:Solid |