BSJ-4-116
规格
| Cas Number | 2519823-34-6 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 100 mg/mL (119.42 mM); Water: Insoluble; Ethanol: Insoluble; |
| 简短描述 | CDK抑制剂 |
| 英文简短描述 | CDK Inhibitors |
| 过滤标签 | CDK,PROTACs,Cell Cycle/DNA Damage,PROTAC |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | BSJ-4-116 是细胞周期蛋白依赖性激酶 12（CDK12）的特异性降解剂。BSJ-4-116 具有强大的抗增殖作用。 |
| 英文描述 |
Information BSJ-4-116 BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12) . BSJ-4-116 exhibits potent antiproliferative effects. Targets CDK12 In vitro BSJ-4-116 selectively degrads CDK12 as assessed through quantitative proteomics. BSJ-4-116 downregulates the expression of DDR genes and exhibits antiproliferative activity in cancer cells. BSJ-4-116 also substantially suppresses the phosphorylation of Pol II Ser2 and Thr4. Cell Research(from reference) Cell lines：Jurkat cells Concentrations：50\u2009nM Incubation Time：8\u2009h |