BYK204165
规格
| Cas Number | 1104546-89-5 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 250mg 或 50mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Soluble in DMSO (10 mg/ml). |
| 简短描述 | 有力和选择性的PARP-1抑制剂 |
| 英文简短描述 | a potent and selective PARP-1 inhibitior |
| 过滤标签 | 表观遗传学,PARP,Cell Cycle/DNA Damage |
| 储存温度 | -20°C储存,充氩,干燥 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | BYK204165 是一种强效的多聚（ADP-核糖）聚合酶 1 (PARP1) 选择性抑制剂。它对 PARP-1 的选择性是 PARP-2 的 100 倍。 |
| 描述 |
BYK204165，也称为PARP抑制剂XIV，是一种细胞可渗透的异喹啉二酮化合物，可有效和选择性地抑制聚（ADP-核糖）聚合酶1（PARP1）。PARP1是一种核酶，参与调节各种细胞过程，例如分化，增殖和肿瘤转化。它也参与分子事件的调控，这些分子事件涉及从DNA损伤中恢复细胞。BYK204165的效价与目前大多数标准PARP-1抑制剂相似或更高（仅略低于PJ34），并且对PARP-1的选择性是PARP-2的100倍。 |
| 英文描述 |
BYK204165, also known as PARP Inhibitor XIV, is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1). PARP1 is a nuclear enzyme involved in the regulation of various cell processes such as differentiation, proliferation, and tumor transformation. It is also involved in the regulation of the molecular events involved in the recovery of cell from DNA damage. BYK204165's potency is similar or higher than most current standard PARP-1 inhibitors (just slightly lower than PJ34), and it is 100-fold selective for PARP-1 over PARP-2 |