CeMMEC1
规格
| Cas Number | 440662-09-9(free base)(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | CeMMEC1 是 BRD4 的抑制剂，对 TAF1 也有很高的亲和力，对 TAF1 的 IC 50 为 0.9 μM，对 TAF1 的 K d 为 1.8 μM（2）。 |
| 描述 |
CeMMEC1 是 BRD4 的抑制剂，同时对 TAF1 有很高的亲和性，对 TAF1 的 IC50 值为 0.9 μM，对 TAF1 (2) 的 Kd 值为 1.8 μM。 |
| 英文描述 |
CeMMEC1 is an inhibitor of BRD4 , and also has high affinity for TAF1 , with an IC 50 of 0.9 μM for TAF1, and a K d of 1.8 μM for TAF1 (2). In Vitro CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC 50 of 0.9 μM for TAF1, and a K d of 1.8 μM for TAF1 (2) and slso shows high affinity for the bromodomains of CREBBP, EP300, BRD9. CeMMEC1 (1, 10, 20 μM) decreases the number of THP1 cells in S phase in a dose manner. CeMMEC1 also induces apoptosis. CeMMEC1 in combination with (S)-JQ1 displays potently impaired cell viability than treatment alone. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Kd: 1.8 μM (TAF1 (2)), IC50: 0.9 μM (TAF1) |