CAY10404
规格
| Cas Number | 340267-36-9 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO: 10 mg/mL (27.22 mM) |
| 简短描述 | COX-2的选择性抑制剂 |
| 英文简短描述 | a selective inhibitors of COX-2 |
| 过滤标签 | COX-2 Inhibitor,COX,Akt,Immunology/Inflammation,PI3K/Akt/mTOR |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 物理形态 | 固体 |
| 描述 |
CAY10404是迄今为止报道的对COX-2最具选择性的抑制剂之一，其选择性指数（SI; SI = IC50 COX-1 / IC50 COX-2）大于500,000。（COX-1 IC50大于500 mM，COX-2 IC50小于1 nM。）作为参考点，塞来昔布的SI约为400。因此，CAY10404的SI比第一代的SI大几倍。具有选择性的COX-2抑制剂，与第二代选择性COX-2抑制剂（如valdecoxib和etoricoxib）的SI相当。 |
| 英文描述 |
CAY10404 is one of the most selective inhibitors of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50 COX-1/IC50 COX-2) of >500,000. (The COX-1 IC50 is >500 mM, and COX-2 IC50 is <1 nM.) As a reference point, the SI of celecoxib is about 400. Thus, CAY10404 has an SI which is several logs greater than the first generation of selective COX-2 inhibitors, and is comparable to the SI of second generation selective COX-2 inhibitors, such as valdecoxib and etoricoxib. |