Cdk1抑制剂
规格
| Cas Number | 220749-41-7 |
| 规格或纯度 | Moligand™, ≥95% |
| 级别 | Moligand™ |
| 纯度 | ≥95% |
| 包装 | 100mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| Action Type | 抑制剂 |
| Mechanism Of Action | 细胞周期蛋白依赖性激酶 1 抑制剂 |
| 溶解性 | DMSO |
| 简短描述 | 吲哚基亚甲基-2-吲哚酮抗增殖剂 |
| 英文简短描述 | an indolylmethylene-2-indolinone anti-proliferative agent |
| 过滤标签 | cyclin dependent kinase 1 Inhibitor |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 描述 |
Cdk1抑制剂是一种吲哚基亚甲基-2-吲哚满酮衍生物，具有有效的抗增殖特性（IC50 = 2 µM HeLa细胞）。Cdk1抑制剂可作为Cdk1 / cyclin B的选择性和ATP竞争性抑制剂（IC | 50 | = 5.8 µM）。还以IC | 50 | = 25 µM抑制Cdk5。绑定到Cdk1活动位点上的ATP口袋。即使浓度为100 µM，也不会影响GSK-3b的活性。 |
| 英文描述 |
Cdk1 Inhibitor is an indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 μM HeLa cells). Cdk1 Inhibitor acts as a selective and ATP-competitive inhibitor of Cdk1/cyclin B (IC|50|= 5.8 μM). Also inhibits Cdk5 with a IC|50|= 25 μM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3b even at 100 μM concentrations. |