cFMS受体抑制剂IV
规格
| Cas Number | 959626-45-0 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 250mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Soluble in DMSO (5 mg/ml). |
| 简短描述 | 细胞可渗透的呋喃羧酰胺化合物 |
| 英文简短描述 | a cell-permeable furan carboxamide compound |
| 过滤标签 | c-Fms,Protein Tyrosine Kinase/RTK |
| 储存温度 | 避光,-20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 描述 |
cFMS受体抑制剂IV是一种可渗透细胞的呋喃羧酰胺化合物，可作为有效，可逆且具有ATP竞争性的c-Fms-CSF-1R（cFMS / CSF-1R）抑制剂。cFMS受体抑制剂IV在无细胞试验和CSF-1 / M-CSF刺激的HEK-293细胞中阻断cFMS自磷酸化。 |
| 英文描述 |
cFMS Receptor Inhibitor IV is a cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive c-Fms-CSF-1R (cFMS/CSF-1R) inhibitor. cFMS Receptor Inhibitor IV blocks cFMS autophosphorylation in cell-free|in vitro|kinase assays and in CSF-1/M-CSF-stimulated HEK-293 cells. A cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive cFMS/CSF-1R inhibitor that blocks cFMS autophosphorylation both in CSF-1/M-CSF-stimulated HEK-293 cells (IC50 = 76 nM) and in cell-free in vitro kinase assays (IC50 = 17 nM). |