Cjoc42
规格
| Cas Number | 2171519-89-2 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 100 mg/mL (240.70 mM; Need ultrasonic) |
| 过滤标签 | Apoptosis,MDM-2/p53 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | Cjoc42 是一种能够与 gankyrin 结合的化合物。Cjoc42 能以剂量依赖的方式抑制 gankyrin 的活性。Cjoc42 可防止 p53 蛋白水平的降低，这种降低通常与大量 gankyrin 相关。Cjoc42 可恢复 p53 依赖性转录。 |
| 英文描述 |
Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin. Cjoc42 restores p53-dependent transcription and sensitivity to DNA damage. In Vitro cjoc42 (0.5, 1, and 5 μM; 48 hours) dose-dependently restores p53 levels (comparable to mock transfected cells) and inhibits gankyrin-induced lowering of p53 levels in cells. cjoc42 (0.1, 1, and 10 μM; 24 hours) alone shows no dose-dependent change in cell viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: U2OS Concentration: 0.5, 1, and 5 μM Incubation Time: 48 hours Result: Dose-dependent restoration of p53 levels (comparable to mock transfected cells) and inhibited gankyrin-induced lowering of p53 levels in cells. Form:Solid |