CU-CPT9b
规格
| Cas Number | 2162962-69-6 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 100mg 或 50mg 或 10mg 或 5mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 83.33 mg/mL (331.62 mM; Need ultrasonic) |
| 过滤标签 | Toll-like Receptor (TLR),Immunology/Inflammation |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | CU-CPT9b 是一种特异性 TLR8 拮抗剂，其 IC 50 为 0.7 nM。CU-CPT9b 与 TLR8 的结合亲和力很高，K d 为 21 nM。 |
| 英文描述 |
CU-CPT9b is a specific TLR8 antagonist, with an IC 50 of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a K d of 21 nM In Vitro CU-CPT9b is a specific TLR8 antagonist, with an IC 50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT9b with a K d of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT9b as compared to TLR8/CU-CPT8m. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TLR8 0.7 nM (IC 50 ) TLR8 21 nM (Kd) |