D-erythro-Sphingosine hydrochloride
规格
| Cas Number | 2673-72-5 |
| 规格或纯度 |
| 包装 | 50mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 过滤标签 | TRP Channel,神经元信号传导,膜转运器/离子通道 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | D-赤藓-Sphingosine（赤藓鞘氨醇）盐酸盐是一种特异性 TRPM3 激活剂。D-erythro-Sphingosine 还能诱导视网膜母细胞瘤蛋白去磷酸化。 |
| 英文描述 |
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation In Vitro Extracellular application of D-erythro-Sphingosine (20 μM) induces an increase in [Ca 2+ ] i in TRPM3-transfected HEK293 cells within 20 to 30 s after start of application, whereas nontransfected control cells (NT) shows only very small responses. D-erythro-Sphingosine (10 μM) induces currents through TRPM3. Induction of retinoblastoma protein dephosphorylation by D-erythro-Sphingosine (500 nM; 24 h) precede inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TRPM3|Retinoblastoma protein |