DASA-58
规格
| Cas Number | 1203494-49-8 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 级别 | Moligand™ |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| Action Type | 激活剂 |
| Mechanism Of Action | 丙酮酸激酶 M1/2 激活剂 |
| 简短描述 | PKM 活化剂 |
| 英文简短描述 | PKM Activators |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | DASA-58 是一种特异性强效丙酮酸激酶 M2 (PKM2) 激活剂。 |
| 英文描述 |
Information DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. Targets PKM2 In vitro DASA-58 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes in primary BMDMs, and also inhibits glycolysis and the accumulation of succinate in LPS-activated macrophages. In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1α. DASA-58 also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells. In vivo DASA-58 (40 μM) affects EMT of prostate cancers and tumor dissemination in SCID mice. |