DTHIB
规格
| Cas Number | 897326-30-6 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | HSF1 抑制剂 |
| 英文简短描述 | HSF1 InhiBitor |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | DTHIB（Direct Targeted HSF1 InhiBitor，直接靶向热休克因子 1（HSF1）抑制剂）是一种直接的选择性热休克因子 1（HSF1）抑制剂，DTHIB 与 HSF1 DNA 结合域（DBD）结合的 Kd 值为 160 nM。DTHIB 具有很强的抗癌活性。 |
| 英文描述 |
Information DTHIB DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities. Targets HSF1 (Cell-free assay) 160 nM(Kd) In vitro Direct Targeted HSF1 InhiBitor (DTHIB) physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation. In vivo DTHIB potently attenuates tumor progression in four therapy-resistant prostate cancer animal models, including an NEPC model, where it causes profound tumor regression. Cell Research(from reference) Cell lines：C4-2, PC-3, BPH-1 cells Concentrations：0.5 μM, 1.0 μM, 2.5 μM, 5 μM Incubation Time：36-hour, 48-hour, 96-hour |