DIF-3
规格
| Cas Number | 113411-17-9(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | GSK-3,Stem Cell/Wnt,PI3K/Akt/mTOR,Compound libraries |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | DIF-3 通过激活 GSK-3β 促进细胞周期蛋白 D1 和 c-Myc 的降解，从而降低它们的表达水平。DIF-3 可抑制 DLD-1 细胞中的 Wnt/β-catenin 信号通路相关蛋白。DIF-3可抑制DLD-1细胞中的Wnt/β-catenin信号通路相关蛋白。 |
| 英文描述 |
DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression. |