DS-7423
规格
| Cas Number | 1222104-37-1(DMSO) |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 过滤标签 | mTOR,PI3K,PI3K/Akt/mTOR,Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | DS-7423 是一种 PI3K 和 mTOR 双抑制剂，对 PI3Kα 和 mTOR 的 IC 50 值分别为 15.6 nM 和 34.9 nM。DS-7423 具有抗肿瘤活性。 |
| 英文描述 |
DS-7423 is a dual PI3K and mTOR inhibitor, with IC 50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR , respectively. DS-7423 possesses anti-tumor activity. In Vitro DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells. DS-7423 also inhibits other isoforms of class I PI3K (IC 50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. |