DKM 2-93
规格
| Cas Number | 65836-72-8 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 25mg 或 500mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 49 mg/mL (201.07 mM); Ethanol: 14 mg/mL (57.45 mM); Water: Insoluble; |
| 简短描述 | E1 激活抑制剂 |
| 英文简短描述 | E1 Activating Inhibitors |
| 过滤标签 | E1/E2/E3 Enzyme,Metabolic Enzyme/Protease |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | DKM 2-93 是一种具有相对选择性的泛素样修饰激活酶 5（UBA5）先导抑制剂。 |
| 描述 |
DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。 |
| 英文描述 |
Information DKM 2-93 DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5) . Targets UBA5 In vitro DKM 2-93 not only impairs pancreatic cancer cell survival in PaCa2, but also Panc1 cells with 50 % effective concentration values of 90 and 30 μM, respectively. In vivo DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity. Cell Research(from reference) Cell lines：PaCa2 and Panc1 pancreatic cancer cells Incubation Time：48 h |