F-1
规格
| Cas Number | 2244775-31-1 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 50mg 或 10mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 过滤标签 | Anaplastic lymphoma kinase (ALK),ROS Kinase,Protein Tyrosine Kinase/RTK,ALK and ROS1 inhibitor |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | F-1是一种强效的ALK和ROS1双重抑制剂，能抑制磷酸化ALK及其相关下游信号通路，对ALKWT、ROS1WT、ALKL1196M\xa0 和ALKG1202R的抑制作用分别为2.1 nM、2.3 nM、1.3 nM和3.9 nM。 |
| 英文描述 |
Information F-1 is a potent dual inhibitor of ALK and ROS1 that suppresses phospho-ALK and its relative downstream signaling pathways with IC50 of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. |