FTY720（R）-磷酸盐
规格
| Cas Number | 402616-23-3 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 1mg 或 500μg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | Soluble in chloroform (~0.5 mg/ml). |
| 简短描述 | 淋巴细胞迁移的免疫调节剂和抑制剂以及S1P激动剂 |
| 英文简短描述 | an immunomodulator & inhibitor of lymphocyte emigration as well as a S1P agonist |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 描述 |
FTY720（R）-磷酸盐，FTY720是一种新型的免疫调节剂，可抑制淋巴细胞从淋巴器官中迁移出来，从而延长了许多模型中同种异体移植的存活时间。鞘氨醇激酶在体内使FTYS20磷酸化，因此FTYS20在5种鞘氨醇-1-磷酸（S1P）受体中的4种中充当强效激动剂。FTY720（R）-磷酸酯是FTY720-磷酸酯的一种立体异构体，但显然不是在体内形成的。FTY720（S）-磷酸酯对S1P1,3,4,5的K | i |值分别为2.1、5.9、23和2.2 nM，而R异构体的结合亲和力低了5-130倍。 |
| 英文描述 |
FTY720 (R)-Phosphate, FTY720 is a novel immune modulator that inhibits lymphocyte emigration from lymphoid organs, which prolongs allograft transplant survival in numerous models. Sphingosine kinases phosphorylate FTYS20 in vivo so that FTYS20 acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors . FTY720 (R)-phosphate is one stereoisomer of FTY720-phosphate, but it is evidently not formed in vivo. FTY720 (S)-phosphate exhibits K|i|values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, while the R isomer binds with 5-130-fold lower affinity. |