G140
规格
| Cas Number | 2369751-07-3 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 250 mg/mL (659.21 mM; Need ultrasonic) |
| 过滤标签 | Cyclic GMP-AMP Synthase,Immunology/Inflammation |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | G140 是一种强效的环 GMP-AMP 合成酶（cGAS）选择性抑制剂，对 h-cGAS 和 m-cGAS 的 IC 50 s 分别为 14.0u2009nM 和 442u2009nM。G140 具有抗炎活性。 |
| 英文描述 |
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity In Vitro G140 (0.1-100 μM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC 50 s of 1.70 and 0.86?μM in human THP1 and primary macrophages, respectively. ?\nG140 (0.1-100 μM; 24 h) inhibits cells viability with a LD 50 of >100 μM in THP1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 14.0 nM (h-cGAS), 442 nM (m-cGAS) |