G150
规格
| Cas Number | 2369751-30-2 |
| 规格或纯度 | ≥98% |
| 纯度 | ≥98% |
| 包装 | 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 别名 | 1-(9-(6-Aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one;1-[9-(6-Amino-3-pyridinyl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-ethanone |
| 品牌 | 阿拉丁 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 78 mg/mL (199.36 mM); Ethanol: 1.5 mg/mL (3.83 mM); Water: Insoluble; |
| 简短描述 | cGAS 抑制剂 |
| 英文简短描述 | cGAS Inhibitors |
| 过滤标签 | Cyclic GMP-AMP Synthase,Immunology/Inflammation |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | G150 是一种强效、高选择性的人类环 GMP-AMP 合成酶（cGAS）抑制剂，IC50 为 10.2 nM。 |
| 描述 |
G150 是一种高选择性的 human cyclic GMP-AMP synthase h-cGAS 抑制剂 IC50 值为 10.2 nM。G150 可抑制 dsDNA 引发的干扰素表达，可用于炎症的研究。 |
| 英文描述 |
Information G150 G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM. Targets h-cGAS (Cell-free assay) 10.2 nM In vitro The most potent h-cGAS-specific derivative with 2-amino pyridine (G150) shows inhibitory activity in THP1 cells and primary human macrophages while a complete absence of off-target effect on a diverse range of sensors. G150 also shows no substantial cellular toxicity. Cell Research(from reference) Cell lines：THP1 cells, primary macrophage cells Concentrations：10 μM and 5 μM Incubation Time：1 h |