GSK620
规格
| Cas Number | 2088410-46-0 |
| 规格或纯度 | 10mM in DMSO |
| 包装 | 1ml |
产品信息
| 品牌 | 阿拉丁 |
| 浓度 | 10mM in DMSO |
| 简短描述 | 表观遗传阅读器域抑制剂 |
| 英文简短描述 | Epigenetic Reader Domain Inhibitors |
| 过滤标签 | Compound libraries |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | GSK620 是一种泛 BD2 抑制剂，在人体全血中显示出抗炎表型，具有出色的广泛选择性、可开发性和体内口服药代动力学。 |
| 英文描述 |
Information GSK620 GSK620 is a pan- BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics. Targets BD2 In vitro GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 is capable of reducing the MCP-1 response in a concentration-dependent manner, providing strong evidence that GSK620 is indeed engaging BD2 in cells. In vivo GSK620 is a potent and selective pan-BD2 inhibitor with excellent in vivo PK properties and excellent developability properties, with the exception of moderate FaSSIF solubility driven by its highly crystalline nature. Cell Research(from reference) Cell lines：human whole blood, hepatocytes Concentrations：0.5 μM Incubation Time：60 min, 120 min |