GDP366
规格
| Cas Number | 501698-03-9 |
| 规格或纯度 | ≥99% |
| 纯度 | ≥99% |
| 包装 | 100mg 或 50mg 或 10mg 或 1mg 或 5mg 或 25mg |
产品信息
| 品牌 | 阿拉丁 |
| 溶解性 | DMSO : 62.5 mg/mL (166.47 mM; Need ultrasonic) |
| 过滤标签 | Apoptosis,Survivin |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 生化和生理学机理 | GDP366 是一种存活素和 Op18 的双重抑制剂，可诱导人类癌细胞的细胞生长抑制、细胞衰老和有丝分裂灾难。 |
| 英文描述 |
GDP366, a dual inhibitor of survivin and Op18 , induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. In Vitro GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Survivin, Op18 |